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What is Phenacetin?

What is Phenacetin?

Phenacetin (chemical formula C10H13NO2) is a white crystalline solid at room temperature with a melting point of about 134℃. Phenacetin is a banned drug in many countries.

For phenacetin, we have shiny phenacetin crystalline powder and non-shiny phenacetin powder.

        What is the function of phenacetin?

        What can phenacetin be used for?

        What should be paid attention to when using phenacetin?


      What is the function of phenacetin?

       Phenacetin has a strong inhibitory effect on the synthesis and release of prostaglandin in the hypothalamus, but the peripheral effect is weak, so the antipyretic effect is good, the analgesic and anti-inflammatory effect is poor. Protoform and its metabolite paracetamol have antipyretic effect, the efficacy of the intensity is comparable to aspirin, the effect of pheacetin is slow and lasting. Mainly used as antipyretic.

      Phenacetin has antipyretic and analgesic effects, but no anti-inflammatory or anti-rheumatic effect.


       What can phenacetin be used for?

       Phenacetin is widely usded in Antipyretic analgesic, used for the treatment of fever, headache, neuralgia, etc. Antipyretic effect is stronger than analgesic effect. The efficacy intensity is similar to that of aspirin, the effect of phenacetin is slow and lasting, and the toxicity is low. The study shows that phenacetin and its metabolite paracetamol have antipyretic effect. Because the enzyme inhibitors of phenacetin can not be converted to paracetamol, can still show a significant antipyretic effect. Therefore, the antipyretic effect of the raw material was not only caused by its active product, acetaminophen. The mild analgesic effect of phenacetin is generally maintained for 3-4 hours. The synergistic effect with salicylic acid can enhance the analgesic effect. Clinically, phenacetin is mainly used for antipyretic analgesia of small animals. Phenacetin is also a component of APC Tablets.

     What should be paid attention to when using phenacetin?

Excessive doses or long-term use phenacetin can cause methemoglobinemia, damage the kidneys and even induce cancer. Other possible adverse reactions include cyanosis reaction and hemolytic anemia resulting in tissue hypoxia or cyanosis. It is easy to cause serious toxic reaction to cats and should not be used.

 

Learn more something about Phenacetin can know the function of phenacetin and the applications of Phenacetin. Hubei Aoks Bio-Tech Co., Ltd can help you to open up a further and larger market, it is wise to choose us as your business partner. Our company has many close relationships with different pharmaceutical raw materials by providing various kinds of compound drugs synthesized by phenacetin.


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